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For further discussion and rationale for the proposed modification or removal of these measures is provided at Table Group DD and Table Group C of this final rule

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Specifically, erianin serves a key role through dual pathways: Erianin effectively induces ferroptosis in bladder cancer cells by inhibiting the NRF2 signaling pathway (65) and, by activating the JNK signaling pathway, triggers cell cycle G2/M phase arrest and promotes apoptosis (66)

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