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A trial of reperfusion therapy for ischemic stroke indicated that semaglutide, which has a strong GLP-1R-mediated neuroprotective effect, could reduce the infarct size in acute ischemic stroke in non-diabetic rats (89)

Malpetti M, Joie R, Rabinovici GD

GLP-1s have not received FDA approval for use in individuals with type 1 diabetes (T1D) due to concerns about increased risks of diabetic ketoacidosis and hypoglycemia associated with short-acting GLP-1s

GLP-1 receptor agonists present a viable alternative, especially for patients unable to tolerate CPAP therapy or those seeking additional support alongside traditional methods

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