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doi: 10.3389/fphys.2017.00439 2 ChiuAVSaighMAMcCullochCAGlogauerM

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In the Yushu state of the Qinghai-Tibet Plateau (3780 m), CMS patients had significantly lower SaO 2 levels than controls, with CMS scores positively related to the apnea-hypopnea index and negatively correlated with the SaO 2 value

It depends on your individual needs, but most people start with weekly injections before switching to monthly maintenance