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Mechanism & Research Background Melanotan II is a synthetic cyclic lactam analog of the -MSH core sequence, constrained by a lactam bridge between its Asp and Lys residues to resist enzymatic degradation and increase receptor affinity
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In mammals, Sec24 has four isoforms, Sec24 A, Sec24B, Sec24C and Sec24D, which offer the possibility of binding diverse COPII vesicle cargoes [24]
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