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However, prolonged or high-dose ketamine exposure induces a compensatory upregulation of NMDARs, increasing intracellular calcium ion influx and ROS production, ultimately leading to neuronal apoptosis ( In animal studies, antagonism of NMDA receptors in intermediate neurons of the forebrain and thalamus reduces GABAergic function

Overall mouse health was assessed by daily inspection for signs of discomfort, weight loss, or changes in behaviour, mobility, and feeding or drinking habits

Neuroprotection and braingut axis: evaluated in TBI, encephalopathy and serotonergic/dopaminergic dysfunction models, with neurobehavioral and histological protection reported [2]

These are called closed arm while the other two arms without walls were called open arm. The lengths of closed and open arms were 35 and 36.5 cm, respectively

The peptide pharmacokinetics paper by He et al