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Mutation site residue H152 and active site residues C46, Q81, and W136 are highlighted and shown as green (H152) or white sticks

Comment: Some commenters noted that the Online delivery period described at 410.79(f) from January 1, 2026, to December 31, 2029 is temporary in nature, and that suppliers may face resource challenges while implementing delivery models under temporary authorization

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Avoiding severe calorie restriction: GLP-1 medications should reduce hunger, not encourage near-starvation