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Mimics natural amylin released by the pancreas, signaling satiety to the area postrema and other brainstem regions involved in appetite control

Each substance demonstrated significant neuroprotective effects in different experimental models, including glutamateinduced toxicity, TBI, and excitotoxic conditions (Table 2)

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Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

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