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In Vitro Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism [1]

The compound was also investigated as PL14736 in early-phase IBD clinical work, as described in a 2008 paper by Klicek and colleagues in Journal of Pharmacological Sciences , though that clinical program was never completed or approved

Moreover, 89Zr-DFO-YS5-PET imaging demonstrated tumor-specific uptake of FOR46

This research benefited from use of the Technion Center of Structural Biology facility of the Lorry I