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Attributed to the selective IR paradox, compensatory hyperinsulinemia can amplify hyperandrogenism via several mechanisms: (i) cross-activation of insulin and/or IGF-1 receptors, which enhances LH-mediated expression of key steroidogenic enzymes (e.g., CYP17A1) in ovarian theca cells and increases androgen synthesis

Maintenance doses vary widelycommonly ranging from 0.5 mg to 2.4 mg weeklybased on individual tolerance, treatment goals, and provider assessment

This can help lower blood pressure by reducing the workload on the heart

Adverse effects are similar in patients using the medication for diabetes to those using the medication for weight loss [67]

Scenarios considered differences in values of cost inputs, quality of life parameters, time horizon, discount rates, and treatment intensification strategies