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Dosage protocols can vary depending on the intended use, treatment plan, and healthcare provider recommendations

In order to investigate this, a two-phase model of APAP toxicity in freshly isolated hamster hepatocytes was developed;25 in phase 1, metabolic activation of APAP occurred with depletion of GSH, but no loss of cell viability

The fact, however, that OvSH exists as thiolate nearly throughout the pH scale, explains its wide pH range antioxidant potency compared to conventional thiols such as glutathione (latter is inherently a stronger reducing agent, but it exists mostly in the inactive protonated form at neutral pH and below)