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This updated strategy is tailored to address established cardiovascular disease, high cardiovascular risk, heart failure, kidney disease, or obesity [5, 6]

Certain groups have been excluded from trials or may face additional risks, including: People who are pregnant or breastfeeding , as the safety profile in these groups has not been established Individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) this exclusion reflects trial protocols and the US prescribing label for some GLP-1 receptor agonists

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Wang S-M, Han C, Lee S-J, Patkar AA, Masand PS, and Pae C-U

Dopamine D2 receptor signaling in the brain modulates circadian liver metabolomic profiles