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Consistent with these effects, GLP-1 RAs have been associated with substantial weight loss in clinical trials, leading to FDA approval of two of these agents liraglutide and semaglutide for chronic weight management in adults with obesity or with overweight and at least one weight-related comorbidity

In recent studies, the health gains for cardiovascular, liver and kidney disease, for example, happen regardless of whether patients lose weight

Discussion The results of our meta-analysis suggested that GLP-1 RAs exhibit the potential to treat OSA in patients with obesity, particularly in terms of reducing AHI, which was consistent with Lis findings [32]

For most people, that difference is smalland for those who would not otherwise use an injectable medication, a pill may be the more practical choice