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The dermis is the major constituent of the skin and is composed primarily of collagen, elastin, and glycosaminoglycans, which provide the skin its elasticity and flexibility (Figures 2AE

Since GSTO1 knockdown has been known to result in increased protein glutathionylation 14 , glutathione depletion by CHAC1 could possibly contribute in restoring the glutathionylation balance

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On the other hand, recent evidence has shown that low or moderate levels of ROS/RNS can serve as second messengers in intracellular signaling cascades involved in various cellular pathways (59)

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