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Manuscript editing, reviewing: MMHC, AJIQ, SR, AP and HAC

3 Results 3.1 Metabolome analysis reveals dominant impact of SLE on the pentose phosphate pathway, nucleotide, cysteine, and kynurenine metabolism Quantitative enrichment analysis of 258 measured metabolites revealed robust changes in the metabolome of SLE patients PBL relative to those of healthy controls matched for age within 10 years, gender, and ethnic background

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