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Toxicity studies confirm good biocompatibility, with no cytotoxicity up to 200 g/mL and no pathological changes in major organs (191)

Proper hydration is a critical, non-negotiable element of effective weight loss

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Of note, metformin and a DPP-4 inhibitor additively increase active GLP-1 levels in the plasma [32], which confers clinical benefits in the management of type 2 diabetes