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- Nausea or stomach upset (common with oral supplements) - Mild skin rashes or itching (possible with topical use) - Temporary bloating or cramping These are usually mild and subside when dosage is adjusted or discontinued

(3) Multitargeted therapy: BBR-isoliquiritigenin (ISL) dual therapy attenuates adipose inflammation and dyslipidemia via IRS1-PI3K-Akt pathway activation in DIO mouse, while BBR-catechin-capsaicin polypharmacology outperforms monotherapies in 3T3-L1 adipocytes [181, 195]