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Importantly, causation remains unclear: some headaches may be coincidental, stress-related, or tied to lifestyle changes accompanying weight loss rather than the medication

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In the muscle cortisol reduces the translocation of the insulin-dependent glucose transporter 4 (GLUT4) to the plasma membrane thereby impairing glucose uptake and by activating glycogen synthase kinase-3 suppresses glycogen synthesis and promotes protein degradation ( Table 1 )