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Gomes 2017)

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Results Long-term BDNF treatment improves excitatory synaptic current frequency and amplitude To investigate the ability of prolonged exposure to BDNF to regulate network dynamics and synaptic transmission, dissociated hippocampal cultures were treated for 4 days with 20 nM mature BDNF (named BDNF-treated cultures) and compared to untreated ones (named Controls)

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In characterization work it was described as the first selective secretagogue, stimulating growth-hormone release in pituitary-cell and animal models without significantly elevating ACTH, cortisol, or prolactin above baseline