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*Correspondence: Xian-Feng Zhang, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Obesity, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Hepatic fat content dropped dramatically a benefit largely attributed to glucagon receptor activation, which directly stimulates hepatic lipid oxidation and reduces lipogenesis

Patients should never stop or adjust their medication without first consulting the prescribing clinician or trial investigator, as abrupt discontinuation may affect metabolic control and overall health outcomes