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Nevertheless, in the context of pathological stimuli such as hypoxia, microbial infection, or tumorigenesis, the levels of exRNA demonstrate a dosedependent increase, attaining concentrations 10to 100fold higher than the baseline [126]

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Mitochondrial Dysfunction in Type 2 Diabetes and Obesity Well established data demonstrate that mitochondrial dysfunction, particularly as it relates to the processes of oxidative phosphorylation, is contributory to the development of encephalomyopathy, mitochondrial myopathy, and several age-related disorders that include neurodegenerative diseases, the metabolic syndrome, and diabetes