In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms
Ramon Vela (04:39.202) Yeah
Some comments requested moving to tiered payment rates in CY 2027 after setting an initial flat payment rate for CY 2026
Frontiers in Pharmacology, 12, 627533.
Semaglutide, a glucagon-like peptide receptor agonist (GLP-1 RA), is the active ingredient in Ozempic and Wegovy, two medications being prescribed with increasing frequency across the US, adding to a cause for concern about the study's findings