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Alluding to the deflation and sagging that can accompany rapid weight loss, the term first penetrated the zeitgeist (or at least our Google search bars) in January 2023 when The New York Times announced: Those Weight Loss Drugs May Do a Number on Your Face. The next spike in curiosity about the phrase came three months later, coinciding directly with a Hollywood Reporter piece on the rise of a related phenomenon: Ozempic body. As the medications melted away fat, people were confronting flaccid skin that no longer fit their frames

Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes