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Advanced / Aggressive Protocol (1 mL = ~5.0 mg/mL) Note: The 12 mg dose represents the highest dose tested in Phase 2 trials [3] [4] , producing maximum weight-loss efficacy (~24% body weight at 48 weeks)

Before he'll write a prescription for a weight-loss drug, Khan talks with patients to find out how seriously they've taken their previous weight-loss attempts, and he discusses the financial burden and potential side effectsincluding the possibility of needing to stay on the drug for life

In general a Cohen's d effect size between 0.2 and 0.4 is small, between 0.5 and 0.7 is medium and 0.8 or above is large