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The prefilled pen is engineered to deliver accurate dosing and ease of use

Statistics and reproducibility Since this was a post hoc study, no statistical method was used to predetermine sample size for the epigenetic aging analyses

Based on HbA1c drift amongst T2D patients treated with metformin reported from the ADOPT study [35], which has been accepted in clinical submissions [36, 37], an upwards 0.14% HbA1c annual drift was applied

Once side effects stabilize at the new dose, they switch back to their preferred day

Even with these favorable conditions, many patients benefit from ongoing treatment at reduced frequency or dose to prevent gradual regain