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For example, a three-month course of lactulose therapy significantly improved sleep quality, reduced daytime sleepiness, and increased sleep duration and REM sleep in patients with minimal HE (31, 33)

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[DOI] [PubMed] [Google Scholar] 67.Falco A.D., Greene-Cramer R., Shurina B.A., Zakian S., Acton T.B., Ramelot T.A., Montelione G.T