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Loss-of-function mutations of GLP-1/Notch signaling components such as the receptor glp-1 , ligands lag-2 and apx-1 , and downstream transcriptional targets lst-1 and sygl-1 cause germline stem cells to enter meiosis prematurely, which is similar to the DTC removal (Kimble and White, 1981

For example, a selective pro-apoptotic Bcl-2 inhibitor Venetoclax has been approved for the treatment of chronic lymphocytic and acute myeloid leukemia [74]

But, ignoring to strategically account for the global implications of reducing obesity could prove costly.

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