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Methods GLP-1 agonists included in the analysis were approved for treatment of obesity (Saxenda, Wegovy, Zepbound) and corresponding formulations that may potentially be used off-label for treatment of obesity (Mounjaro, Ozempic, Rybelsus, Victoza)

Key Takeaways Yes, Wegovy injections can hurt, but the pain level varies widely

Experimental procedure included 20L as injection volume with a flow rate of 0.7 mL/min, ESI negative ionization, a dwell time of 50 ms, and MRM transitions

24 weeks: Reduction in surface dullness, improved hydration, some fading of very recent postinflammatory hyperpigmentation (PIH) for some individuals

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