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A 2025 matched-cohort study found men who started testosterone therapy had significantly higher rates of tendon tears and repairs at one and two years compared to controls, a pattern the authors attributed to testosterone's effect on tendon biomechanics outpacing the tissue's regenerative capacity Sherman et al

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People often do best when they focus on eating enough protein to help preserve muscle mass, building regular movement into their week, and gradually improving sleep and routines where possible