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Microbiome 9 , 226 (2021)

The enhanced proliferative response of vascular smooth muscle cells was shown to be caused by the inactivation of the SH2 domain-containing protein tyrosine phosphatase 2 (SHP-2 phosphatase) by glutathionylation to allow for the sustained phosphorylation and activation of the tyrosine kinase ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase)

A pre-existing condition of the same may get worsened

Clinical trial data shows increased incidence of biliary disease, likely related to rapid weight loss and altered bile composition during metabolic changes