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GLP-1 receptor agonists also exert antioxidant, anti-inflammatory, and antifibrotic effects by downregulating pro-inflammatory pathways (e.g., nuclear factor-B), cytokines (e.g., transforming growth factor ), and T-cell proliferation [18]

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The high potencies and relative balance of 16 at all three mouse-specific receptors, as well as the long half-life of this compound in minipigs (75 h, Table 2) encouraged us to take this compound forward for pharmacodynamic evaluation in DIO mice

They come up in longevity and body-composition clinics, which is a different use case