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Back Roberts, R (9 Dec 2015) 'Sickening Sweet', Science Institute Museum and Library

The team explored several pathways, including the PI3K/Akt pathway, which affects pancreatic duodenal homeobox 1 (PDX1) and Forkhead box O1 (FoxO1) transcription factors, essential for cell proliferation

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(10 g or 10 ng/kg/day), topical (1.0 g in cream), or per-oral (0.16 g/mL in drinking water) over 90 days and described directional improvements across biomechanical, functional, macroscopic, and histological endpoints, though specific effect sizes and p-values are not reported in the abstract

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