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One of the most pressing challenges is the efficient delivery of biologics to cardiac tissues

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The disparity of ARIs in alleviating cataract progression between animal models and humans can be related to interspecies variations in aldose reductase activity and distinct mechanisms involved in glucose metabolism

Debido al principio de precaucin basado en los datos animales, la FDA requiere que estos medicamentos incluyan una advertencia de recuadro negro (boxed warning) sobre el riesgo terico de tumores de clulas C tiroideas, indicando que se desconoce si estos hallazgos en roedores son relevantes para los humanos

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