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When observational studies report a small uptick in thyroid cancer overall, much of that signal involves papillary tumors, which complicates any simple story about C-cells and calcitonin

But efficacy data from trials reflects population averages individual responses vary significantly, and there are multiple valid reasons to make this change

a loss of 20% therefore means that these people have lost almost 25 kg during the treatment and it is certain that losses of this magnitude, if maintained in the long term, will have positive effects on health