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Canadas drug agency recognises several of these liraglutide, naltrexone-bupropion, orlistat, and semaglutide as effective at producing clinically significant weight loss over at least a year

Other companies, including Terns Pharmaceuticals (TERN-601), Structure Therapeutics (GSBR-1290), and Viking Therapeutics, have oral GLP-1 programs at earlier stages of development, but none has reached Phase 3 or generated the depth of clinical data available for orforglipron

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Some people find that taking their injection on a day when they have a lighter schedule reduces stress-related nausea amplification