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In addition, significant and/or rapid falls in BMI below defined safety thresholds should prompt a pre-specified (i.e., described in the study protocol) assessment for nutritional deficiencies, lean body mass, and functional status, and, if needed, pre-specified interventions

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The nasal mucosa is highly vascularized, allowing absorption directly into circulation, and some evidence suggests nasal administration may provide more direct central nervous system access via the olfactory pathway

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Official WeightWatchers statement Weight Watchers has announced on their official website that the FDA has removed semaglutide from the shortage list and prohibited compounding pharmacies from selling compounded semaglutide