370 BGP-15 enhances HSP70 expression and reduces mutant huntingtin aggregation in HD models, 371 while YM-1 increases HSP70 activity through modulation of its co-chaperone Hsp40, leading to reduced tau aggregation in AD models
Despite the recovery of exercise-induced depleted plasma CoQ 10 level, the athletes biomarkers of muscular damage and physical performance remained unchanged [16]
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MOTS-c treatment in mice has been shown to significantly enhance physical performance across different age groups, including young, middle-aged, and old mice
In contrast, therapeutic strategies targeting other HSPs, including HSP70, HSP27, and B-crystallin, remain at an earlier stage but have demonstrated encouraging results in preclinical cardiovascular models