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For example, in humans, it typically takes years to develop visual field loss, and treatment typically starts long time after the onset of disease, whereas in these mice, neurodegeneration starts at 5 W (EAAC1 KO mice) or 3 W (GLAST KO mice) and the treatment was started at the onset of neurodegeneration

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Gironi M, Borgiani B, Farina E, Mariani E, Cursano C, Alberoni M, et al