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In addition, we did not observe increased deposition of GAG from FOXO4-DRI pre-treated PDL9 chondrocytes (Figure 3C)

Importantly, metabolomic data revealed concurrent reductions in collagen biosynthesis intermediates (trans-3-hydroxy-L-proline, glycine, L-proline) and fibroblast-activating lysophospholipids, supporting that Retatrutide induces coordinated suppression of pro-fibrotic programs at both transcriptional and metabolic levels

J., Yang, L., Deng, L

First, the VAT reduction was durable while treatment continued (about 18% sustained over 52 weeks, with parallel triglyceride improvement)

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