GLP-1 medications have multiple different mechanisms in the body that help with diabetes and weight loss, including: Increasing the amount of insulin made by the pancreas , which helps control blood sugar in patients with diabetes Decreasing the amount of excess sugar made by the pancreas , which helps control blood sugar in patients with diabetes Slowing down digestion from the stomach , which results in feeling full for longer after eating Signaling to your brain that you are full after eating , which helps suppress appetite and control cravings Tirzepatide contains an extra mechanism of action that other GLP-1 medications do not, known as GIP (glucose-dependent insulinotropic polypeptide) agonism
Gironi M, Bianchi A, Russo A, Alberoni M, Ceresa L, Angelini A, et al
When coming off a GLP-1, watch for increased hunger and food noise persistent, intrusive thoughts about food as well as a diminished ability to feel full with smaller portions
Serious side effects are possible
PMID: 40154487