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Mol Cell Endocrinol 418:4254 Lorenz M, Evers A, Wagner M (2013) Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity

Randomized controlled trials before the issue of CVOTs by the FDA in 2008 mainly focused on the efficacy of the blood glucose-lowering effects and a broad spectrum of adverse effects, with limited numbers of cardiovascular adverse events and relatively short follow-up duration

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Whether GLP-1 medications have direct or indirect effects on the menstrual cycle independent of weight loss is a question researchers are now better positioned to study, in part because of work like this