It is usually between 30 to 90 days when stored properly
For semaglutide-based weight loss protocols, the Endocrine Society recommends monitoring weight, glycemia, heart rate, and gastrointestinal tolerability at each dose escalation
Compounded semaglutide can remain stable at room temperature (below 86F / 30C) for up to 24 hours, but refrigeration is always preferred
By month three, reduced food intake can lead to subclinical deficiencies in iron, calcium, vitamin D, B vitamins, and zinc
Potential benefits of split dosing include reduced GI side effects (lower peak concentration), more consistent appetite suppression throughout the week, and better tolerance at higher doses