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Fonseca, M
2A, left-hand panel, higher magnification insert)
Hence, it is likely that NAPQI leads to oxidation of one or more enzymes involved in the conversion of methionine to cysteine, preventing GSH resynthesis from this precursor in phase 2, whereas with NAC such inhibition does not prevent GSH resynthesis.26 Recent studies have provided evidence that cystathionine beta -synthase and cystathionine gamma -lyase, necessary for the conversion of methionine to cysteine, are targets for thiol oxidation by NAPQI.27 Following treatment with NAC, the resulting GSH can act both to detoxify NAPQI by conjugation and to reverse toxicity by thiol reduction
Use KLD Solution (sterile, lab-grade solvent) if your protocol requires reconstitution
Curr Psychiatry Rep
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