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Oxidative stress is associated with amyloid-- or tau-induced neurotoxicity, which results in impaired synaptic plasticity, neurotransmitter imbalance, and neuronal loss, leading to cognitive impairment (Huang et al., 2016

Due to its long half-life, Tirzepatide can continue to exert metabolic effects for several weeks after the last dose, especially a high dose of Tirzepatide

The cardiovascular data strongly supports continuation

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While in vitro equilibrations between redox couples such as roGFP2 and GSH/GSSG require minutes or even hours to reach a thermodynamic endpoint (G = 0), enzyme-catalyzed thiol-disulfide exchange reactions usually occur very rapidly and either maintain or reach a steady state (G 0) 7,31,32,60,63,67,78,79