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J Ovarian Res 17:9 Helvaci N, Okan YB (2025) Polycystic ovary syndrome as a metabolic disease

406 FGF21 is recognized as a stress response factor that addresses mitochondrial dysfunction in cells

Important questions include Whether long term use is anticipated What is known about discontinuation How maintenance is approached if therapy changes Follow up analyses from randomized controlled trials show that discontinuing GLP 1 therapy is commonly associated with a return toward baseline weight or metabolic set point

Notably, weight loss did not always correlate with improved clinical outcomes in patients with HF

Panday, A., Sahoo, M