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and ultimately attenuating gut permeability and metabolic endotoxemia, thereby hindering proinflammatory signaling pathways (25, 31, 34, 35)

Together, T2D and obesity are regarded as potential risk factors implicated in the development and progression of Alzheimers disease (AD), which is the most common neurodegenerative disease and represents the most typical cause of dementia

Full medication disclosure is essentialpatients should inform their provider about all prescription medications, over-the-counter supplements, and the specific dose and formulation of any niacin products they are taking or considering

The General Medical Council (GMC) and NICE guidance support patient-centred care that acknowledges real-world behaviours whilst prioritising safety and treatment efficacy