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Gastrointestinal side effects are the most frequently reported adverse reactions to GLP-1 receptor agonists, affecting a significant proportion of patients, particularly during initial treatment or dose escalation

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Randomized control trials were evaluated using Physiotherapy Evidence Database [16] (PEDro) scale, and the score are represented in Table 1

However, these benefits were based on clinical endpoints and did not include direct measures of renal fibrosis, such as histology or fibrosis-specific biomarkers [55]

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