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Ill explain the glutathione-S-transferase genes and the impact that genetic variants have on phase II detoxification

[DOI] [PMC free article] [PubMed] [Google Scholar] Jaja-Chimedza A, Graf BL, Simmler C, Kim Y, Kuhn P, Pauli GF, Raskin I

140 In clear-cell ovarian cancer (OCCC), the glutaminase inhibitor CB-839 inhibited ARID1A (AT-rich interactive domain-containing protein 1A) -mutated PDX tumor growth

Analysis of the large VITATOPS study, which was a cohort of 1,400 participants expanding over 10 countries, found a significant reduction (~4 mol/L) in homocysteine in the group receiving vitamin B12, folate, and vitamin B6 supplementation compared to the control (29, 30)

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