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However, this study has notable clinical limitations: The second cohort (Cohort 2) only included 24 patients, confounding factors such as diet and concurrent medications were not adjusted for, and there is a lack of clinically standardized protocols for MDSC function detection
& Baba, R
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55,57 In the LEADER trial, at 36 months, there was no difference in the levels of calcitonin between participants in the placebo or liraglutide arm and no diagnoses of C-cell hyperplasia or MTC in those who received liraglutide and there was one event of MTC in the placebo arm
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