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54 In man, Ang II also exerts vasoconstriction, sodium retention and aldosterone secretion through AT 1 receptor stimulation, and drugs inhibiting Ang II formation or selectively blocking the AT 1 receptor are highly effective antihypertensive agents

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CBD functions as a TRPV1 agonist, desensitizing the receptor and mitigating ROS-mediated overactivation of TRP channels, which could otherwise disrupt calcium signaling and contribute to oxidative stress 167

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