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A target of 64-80 ounces of fluid daily is appropriate for most patients (with adjustments for heart failure or kidney disease), with modifications based on activity level, climate, and gastrointestinal losses

Islets 1 (3), 266268 (2009)

Combination therapy has also resulted in improved glucoregulation via an increase in insulin sensitivity, an observation that has been linked to the recovery of pancreatic -cell function 21

It is possible that the increased physical activity that is made possible when people lose substantial amounts of weight could result in the appearance of joint symptoms that were previously masked by inactivity

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